preparation of [64cu] pyruvaldehyde-bis (n4-methylthiosemicarbazone) complex as a pet and/or therapeutic radiopharmaceutical

Authors

a.r. jalilian cyclotron & nuclear medicine department, nuclear research center for agriculture and medicine, karaj, iran

p. rowshanfarzad

j. moafian

m. kamali-dehghan

abstract

background: copper-64 (t1/2=12.7 h) is an important radionuclide used both in pet imaging and therapy. [64cu]-pyruvaldehyde-bis (n4-methylthiosemicarbazone) ([64cu]-ptsm) is one of the most famous copper radiopharmaceuticals with unique specifications (suitable half life, stability, etc.). the wide range of 64cu applications arouse great interest for its production. materials and methods: cu-64 was produced via the 68zn (p, α n) 64cu nuclear reaction and isolated from the irradiated target by a two-step chemical method. [64cu]-ptsm was prepared using in-house made ptsm ligand and [64cu] cuprous acetate. the complex formation parameter s (time, temperature, concentration and elution methods) were determined carefully. results: copper-64 was prepared in chloride form (≈200 mci, >95% chemical yield at 180 μa for 1.1 h irradiation, radionuclidic purity >96%, copper-67 as impurity). the solution of 64cu-ptsm was prepared in >80% radiochemical yield and more than 98% radiochemical purity. quality controls and stability tests were performed for the final solution. conclusion: [64cu]-ptsm was prepared at the radiopharmaceutical scales with high quality and potential to be used in therapeutic/imaging centers. iran . j. radiat. res., 2004 2 (3): 107-115

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Journal title:
iranian journal of radiation research

جلد ۲، شماره ۳، صفحات ۱۰۷-۱۱۵

Keywords
[ ' h y p o x i a i m a g i n g ' , ' c y c l o t r o n ' , ' t a r g e t e d t h e r a p y ' , ' p t s m ' , ' c o p p e r ' , 6 4 , ' p e t ' ]

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