preparation of [64cu] pyruvaldehyde-bis (n4-methylthiosemicarbazone) complex as a pet and/or therapeutic radiopharmaceutical
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abstract
background: copper-64 (t1/2=12.7 h) is an important radionuclide used both in pet imaging and therapy. [64cu]-pyruvaldehyde-bis (n4-methylthiosemicarbazone) ([64cu]-ptsm) is one of the most famous copper radiopharmaceuticals with unique specifications (suitable half life, stability, etc.). the wide range of 64cu applications arouse great interest for its production. materials and methods: cu-64 was produced via the 68zn (p, α n) 64cu nuclear reaction and isolated from the irradiated target by a two-step chemical method. [64cu]-ptsm was prepared using in-house made ptsm ligand and [64cu] cuprous acetate. the complex formation parameter s (time, temperature, concentration and elution methods) were determined carefully. results: copper-64 was prepared in chloride form (≈200 mci, >95% chemical yield at 180 μa for 1.1 h irradiation, radionuclidic purity >96%, copper-67 as impurity). the solution of 64cu-ptsm was prepared in >80% radiochemical yield and more than 98% radiochemical purity. quality controls and stability tests were performed for the final solution. conclusion: [64cu]-ptsm was prepared at the radiopharmaceutical scales with high quality and potential to be used in therapeutic/imaging centers. iran . j. radiat. res., 2004 2 (3): 107-115
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Journal title:
iranian journal of radiation researchجلد ۲، شماره ۳، صفحات ۱۰۷-۱۱۵
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